CLUE AncillariesChemistry, Life the Universe and Everything (CLUE) is a transformed general chemistry curriculum, developed by an interdisciplinary team of a chemist and a molecular biologist, that aims to bring about evidence based change in general chemistry. CLUE was developed using a design research approach that focuses on scaffolded progressions around four core ideas: structure and properties, bonding and interactions, energy, and change and stability. The materials developed include a text (supplied free to students), lecture support materials, workshop/recitation activities, video mini-lectures, and formative and summative assessment materials.